Drugs

Drugs on RSD Alert

(notes and comments from correspondents)

MST

Description
A proprietary preparation containing morphine (a controlled narcotic drug, which is the principal alkaloid of opium). Also known as Morphine Sulphate, MST is normally taken twice a day and is designed as a slow release variant of Morphine.
Side effects

(Don't be unduly alarmed. All drugs cause side effects for some patients)

Nausea, vomiting, loss of appetite, urinary retention, confusion, mental detachment, sedation.
Warnings

(These are standard cautions but may not apply in your case)

Should not be administered to patients who have depressed breathing and should be used with caution with patients who have low blood pressure, impaired liver or kidney function of under-activity of the thyroid gland. Avoid using for pregnant or nursing mothers.

Comments

MST is Modified Morphine Sulphate BP, SR tablets. I take 2x30mg twice a day and have found it to be wonderful. However, I know that others have had problems on this drug and I have been told that doctors have no way of weaning people off MST. I also take Gabapentin, Fluoxetine, Clonazepam and Zopiclone. Pebbles - a member of RSD_UK Group

My pain got so bad recently that I turned up at my hospital doctors clinic on the 1st October without an appointment and demanded to be seen!! The doctor has now put me on a drug called MST. This is a slow release morphine sulphate drug and the difference is amazing! My pain level has really dropped. For now, at least, I am not going to completely get rid of the pain - but what a difference! The dose has to be increased gradually in order that I don't overdose, but it really helps. It is a slow process in getting up to a high enough dose to make a real difference, but the signs are all there that this is my lucky break. I am now on 20mg twice daily and am impressed (very hard to believe after 2½ years of bad pain in both legs. Mickey - Isle of Sheppey, Kent, UK

I was taking MST 4 x 30mg tabs a day 2 in the morning and 2 at night, but they had little or no effect, so I stopped taking them and all my other meds as well because they just made me into an aggressive zombie and did not help with pain. Paul - Guisley, Yorkshire, UK

A very close friend of mine was put onto MST last year, by her doctor. She later became adicted to the drug, started to inject it and has since contracted Hepatitis C. MST never really helped with the pain. As Iwork as a health care profesional I have had previous experience with this drug. I have never seen it give any real benefits. It often seems to cause violence and aggession, and a zombie like state in users. I think doctors are far to quick to perscribe this drug, with out any real warnings to the patient. Lin - Bedfordshire, England

My partner has been taking MST since August 2003 after 3 years on Pethidine. His mood swings following August were quite visible and by November 2003 he became clinically depressed.
He was on 120mg per day - because no-one knows what else to do, his consultant has upped the dose 2 weeks ago (Sept 04) to 160mg per day - along with numerous other drugs. He hasn't noticed much difference in the pain reduction, his depression is still really bad. They are talking of fitting him with a morphine pump, but am concerned this will continue the depression linked to morphine. Kate - England

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